Here's what I've come up with..
Two of the baddest processors on the market, bar none, a solid motherboard to hold them in with all the new technology (USB 3.0, Sata3, quad channel RAM, etc..), one of the fastest SSD's available, and a beast PSU to power it all.
All you need to do is pick a couple things.
Storage - How much storage space do you need? Whatever you need, pick out enough WD Caviar Blacks (regarded as some of the most reliable HD's) to do the job. RAID if you like, not mandatory but makes it a better machine.
RAM - I'm not sure how much you need, but get a little extra whatever it is. It needs 240 pin DDR3, just like everything else. 1600mhz+ since that's what your motherboard supports, although faster RAM isn't going to be very noticeable. I prefer the Corsair Dominator series. Get the ones with the bigger heatsinks.
Cooling - Your best option is go with a custom liquid cooling setup. Shouldn't cost more than a couple hundred from the right place.
GPU - I don't know what you plan on doing with the computer, so I figured I'd leave this one up to you. If you want to game, pick out as many 680's or 7970's as you think you'll need and SLI/Crossfire them up. For professional graphics, (not gaming) check out the ATI FirePro's (
HERE)
Case - I have no idea
Just my opinion on the whole thing.. And I built without a budget, since you didn't give one.