I have an iMac and I've botted using RiD, however I just use their free guide for how to set up a virtual machine. Took me 15 minutes to set up the first time, and after that, it was smooth sailing.
That's right. I got it working on a Simba VPS, and I was then able to show a couple of guys at school who used to bot Pre Bot Nuke how to get it going on their Mac. I haven't seen any complaints.