You don't really need a guide to do that as it's so simple to do. Pretty sure something for that would exist somewhere.
To insert hyperlinks into a signature where they will go to vouches and questing services, cut out the part of the signature you want to lead somewhere, then save and upload that as a separate image, then you can align them in your signature so, it will all still look like one image but different parts of it will lead somewhere if you click a certain part of it. If you're having trouble with this, feel free to drop me a PM and I will happily help you.