Depends what you do.
- There's overload boxing, which you need 95/96 herblore for. Not sure if you can use some potion to gain levels or not, if you don't have 95/96 herblore. You would also need maxed combat (99 attack/defence/strength/hitpoints).
- There's polypore staking. You would need 99 mage for this and maxed combat.
- There's normal boxing, which you need maxed combat for. I don't think many people do normal boxing now-a-days though.
On RS3 there are always stalls people use to gain pid (last hit basically) that gives them huge advantage in stakes, and other things you need to watch out for.