Hum I don't think you should do that because if the problem is that you got 2 def, turning it into 40 wont make anything, bet you'll do the same error and you'll go to higher and higher...
If not, I'd suggest you to keep a pure because when you pvp/bh you lose WAY less worthy stuff instead of 40 defers that always lose full rune + berserker + dds.
But if you're rich/you don't care of losing items in bulks/you have time to do barrow gloves, torso, fire cape and so on, you can do it.