It's pretty questionable whether they can or not, but I used an auto-clicker from about 25-58 mage through teleports and alching without a ban so It's really hard to say.
No one really knows, but it doesn't hurt to be safe. Arte Alch on RSbuddy is an alcher that slightly moves the mouse cursor in random directions when alching.
I believe the more obvious issue is breaks. If you've never been reported before and all of a sudden you are. If you get investigated and they notice unusual activity on an account, it's almost guaranteed ban right there.
depends a simple same milisec clicker will definitely be caught at even a short period of time where as one that has many algorithms will have a lot better chance at getting caught.