I go 2 columns of runes on the left side, followed by (4) of my most used pots at the top row. Then within the first area without scrolling down I have my melee sets, my range sets, cash, arrows, weapons, ect.
Below that I have (3) (2) (1) of every pot I have. Under my runes I have all the skilling items in that 2 column area on the left side. My bank pretty much goes to shit after that with questing items and random stuff I use like magic sec, torso, boots of lightness ect ect.