really depends on how much you do it and what you are doing.
Don't use it for alch as its done by a lot of people already, use an randomized autoclicker (which can be found in runescape 2 cheating section), but for some tasks you can do it and pretty safe.
Just make sure you do interact with the client once a while and start a fresh recording every couple minutes.
It is very safe,i used to use it alot, now not so much as im on private servers more, i used to use it for chiselling granite (5kg) into 500g pieces for profit, but as im f2p i dont/cant.