If you have been following the Runefest of 2011, he says that now that they have all the Reflection bots out of the way, autoclickers will be focused more on.
And they were saved for last due to their easy detectability.
No its not safe, if the autoclicker is clicking on one pixel every time at the same rate, then ROFL, your account will be banned in hours... If you can change the pixel it clicks on and the speed, then you'll be fine, but botting is never safe.
Autoclick it, but just babysit it, play something else on your computer/watch TV or movies and have your screen re-sized. Talk to people every once in a while and make sure you complete all random events accordingly and quickly.