Running HD full screen right now with everything set to max, but I find that turning anti-aliasing off gives me a couple more frames and stability, and doesn't visually change anything
I set it to maxed details, 4x AA, etc. etc. My new ATI HD5770 can handle wimpy old Runescape.
I use resizeable also, but I don't use "any size". I set the max size to the setting so that the chatbox and the skill, inventory, etc tabs are all in a line with no gap at the bottom. I hate having to click a teeny, tiny Inventory tab. >_<
You know some people lag with full HD settings etc, is this down to pc specs or internet bandwidth? for me i have a gaming pc, 4GB RAM, 1GB graphics Card etc, but i have a poor internet speed and i get lag but considering i bot most of the time, it doesn't matter too much