I'd suggest you getting Slades Runecrafter, and do Bloods or Deaths.
Dont do Nature runes, as its medium ban rate, due to all of those goldfarmers as its soo easy to get the reqs.
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Slades Runecrafter
-Nats are horrible but if you have a Runecrafting level lower than 65 then you should do them
-At 65 you should do all the quests for Deaths and do them
-At 77 you should do Bloods
Bloods and Deaths should be done through the Abbyss.