Hey dude, well according to wikipedia:
"The series focuses on Shadow Moon, who meets a strange man named Mr. Wednesday after being released from prison. Shadow Moon soon becomes embroiled in a large-scale conflict between the Old Gods and the New Gods"
The interesting part about it is that show you how old gods (Anubis, thor, zeus) and other mythological entities came to America and how they interact with the new gods (Internet, sex and television).
In Rotten Tomatoes it has a 95% rating but as always the book is better.